Principles of Vaccine Protection

Principle 7: T-cell responses may be correlates of protection

The numerous functional classes of T-cells are suspected to be correlates of protection despite limited knowledge about them.

CD8+ T-cell cytotoxicity is one of the most important protective functions. In addition, CD4+ T cells influence protection directly or indirectly through cytokine secretion.

Principle 8: More than one factor may protect as co-correlates of protection

Multiple factors may function as co-correlates of protection.

Example: The live, attenuated intranasal influenza vaccine generates both nasal IgA mucosal antibody and serum antibody. Vaccinated children who were challenged with another dose of the intranasal vaccine demonstrated three different responses:

Virus shedding happened at a high rate in vaccinees lacking both responses, at an intermediate rate if only one response was present, and at a low rate in vaccinees having both responses.

Therefore, the two responses were synergistic or at least additive.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.